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No particular dose adjustment encouraged when tofacitinib coadministered with strong CYP2C19 inhibitors; decrease tofacitinib dose if coadministered with both average CYP3A4 and powerful CYP2C19 inhibitors .modafinil will lessen the level or impact of mavacamten by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.Modafinil h